全面致心律失常评价
产品名称： 全面致心律失常评价
英文名称： Multi Ion Channel Effects (MICE)
产品编号：
产品价格： 询价
产品产地： null
品牌商标： null
更新时间： null
使用范围： null
- 联系人 : 无
- 地址 : 北京市经济技术开发区科创十三街18号院16号楼
- 邮编 : 100176
- 所在区域 : 北京
- 电话 : 185****7260 点击查看
- 传真 : 点击查看
- 邮箱 : caisw@ice-biosci.com
新药研发过程中，药物的致心律失常毒性越来越受到关注。FDA即将推出的新指导原则全面致心律失常的心脏安全性评价（CiPA）又会给心脏安全性评价带来怎样的变革。爱思普普已准备好CiPA相关的所有离子通道。
|
Channel |
KV11.1,hERG,IKr |
|
Catalog Ref. |
ICE-HEK-hERG |
|
Gene |
KCNH2 |
|
Sources |
human |
|
Expression system |
HEK293 |
|
Method |
whole cell patch clamp |
|
Reference Inhibitor |
E4031, cisapride |
|
Target |
QT-prolongation, Torsade de Pointe(TdP) |
2. Nav1.5离子通道
|
Channel |
NaV1.5 |
|
Gene |
SCN5A |
|
Catalog Ref. |
ICE-HEK-Nav1.5 |
|
Sources |
human |
|
Expression system |
HEK293 |
|
Method |
whole cell patch clamp |
|
Reference inhibitor |
TTX (1.0μM± 438.7nM) |
|
Target |
Brugada syndrome, long QT syndrome, progressive cardiac conduction disease ,dilated cardiomyopathy, sick sinus syndrome, and atrial fibrillation |
3. Cav1.2 离子通道
|
Channel |
Cav1.2/β2/α2/δ1, L-type |
|
Catalog Ref. |
ICE-CHO-Cav1.2 |
|
Gene |
CACNA1C |
|
Sources |
human |
|
Expression system |
CHO |
|
Method |
whole cell patch clamp |
|
Reference Inhibitor |
Nifedipine(31.3nM±6.8nM), verapamil |
|
Target |
Timothy syndrome, long QT syndrome, Pain, epilepsy, hypertension, stroke, arrhythmia, Autism |
4. Iks离子通道
|
Channel |
KvLQT/minK, IKs |
|
Gene |
KCNQ1/KCNE1 |
|
Sources |
Human |
|
Catalog Reference |
ICE-HEK-IKs |
|
Expression system |
HEK293 |
|
Method |
whole cell patch clamp |
|
Standard time |
2 weeks |
|
Reference compound |
Chromanol 293B (1.5µM±0.171µM) |
|
Target |
Atrial fibrillation |
